Imprint - Scientist, Molecular Biology & Immunology

This is an exciting opportunity for a scientist to join a fast-paced, fast-growing research organization based in SoHo. We are seeking a scientist to develop and run novel workflows for adaptive immune cells. The successful candidate will have experience in B and T cell isolation, flow cytometry, tissue culture, and sequencing – and can perform hands-on wet lab experimentation with a variety of immunological assays.  The successful candidate will develop novel immune repertoire assays and datasets, working closely with our multidisciplinary team of senior scientists and computational immunologists.

IMPRINT is a biomedical Focused Research Organization(FRO) building and applying experimental and machine learning tools to identify the hidden causes of chronic disease, especially autoimmune and psychiatric disorders. FROs are moonshot nonprofit startups. Combining the excitement and efficiency of startups with the scientific impact of academia, this role offers hybrid experience in both industry and academia. Our work involves cutting-edge research at the intersection of immunology, machine learning, neuroscience, and disease. 

• Immune cell isolation, tissue culture, and sterile technique
• Design, plan, and execute NGS-based assays in coordination with interdisciplinary science teams
• Prepare DNA and RNA library preparation from immune cells
• Help develop novel sorting methods for B and T cells
• Help develop multi-omics sequencing workflows (e.g., 10x Genomics, LIBRA-seq)
• Analyze and present data
• Creatively solve challenging experimental problems
• Setup, operate, and maintain instrumentation (incubators, shakers, flow cytometer, sequencers)
• Assist in procurement and maintenance of supplies, chemicals, and biological inventories
• Perform other duties as requested

• PhD in Molecular Biology, Immunology, Biochemistry, Bioengineering or related fields is required OR a BA/MS with >5 years industrial experience
• At least 5 years of hands-on research experience with immunology techniques is required
• At least 1 year of experience conducting milestone-driven R&D is required (industry, startup, ARPA experience, or equivalent)
• Demonstrated proficiency in molecular biology and sterile techniques 
• Creative thinking and problem-solving skills
• Strong quantitative and analytical skills
• Strong communication and teamwork skills
• Ability to set priorities and meet deadlines
• Ability to adapt to changing projects and goals
• Passion for breaking barriers in immunology

• Experience with antigen labeling
• Experience with antigen generation
• Experience with adoptive transfer
• Experience with bulk or single-cell sequencing (wetlab) and analysis (bioinformatics) 
• Experience with AIRR-seq / BCR-seq or LIBRA-seq
• Experience with any of following: antibody isolation from plasma, directed evolution
• Proficiency coding in Python/R/Matlab, esp. for data analysis
• Familiarity with project management methodology
• Experience with primary human sample processing (i.e., PBMC, plasma, tissue)
• High proficiency with nucleic acid preparation from adaptive immune cells
• Proven track record of custom library-preparation development for next-generation sequencing

• Competitive salary: $100,000 - $120,000 a year (salary commensurate with relevant experience and adjusted for location)
• Health, vision, and dental insurance
• Generous time off and paid holidays
• Company 401(k) match up to 6%
• Wellness allowance