Senior Research Associate, Process Development

Landmark Bio translates groundbreaking research into life-changing medicines. We provide development, manufacturing, and regulatory capabilities to help early-stage life science innovators rapidly progress advanced therapies from bench to clinic. Launched in 2021, and based in Watertown, Mass. Landmark Bio is an unprecedented venture bringing together the best of industry, academia and research hospitals to accelerate life sciences innovation. A public benefit company, our work advances emerging technologies, demonstrates therapeutic potential, and improves human health.

Our founders include Harvard University, Massachusetts Institute of Technology, FUJIFILM Diosynth Biotechnologies, Cytiva, and Alexandria Real Estate Equities, Inc. Collaborating partners include Massachusetts General Hospital, Brigham and Women’s Hospital, Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute and Boston Children’s Hospital.

We are seeking a highly motivated and team-oriented professional with entrepreneurial spirit to join our company! This is an exciting opportunity for a well-qualified candidate to join a rapidly growing company focused on turning today’s cutting-edge research into tomorrow’s breakthrough therapies. Together with our partners and collaborators, we are effecting broader changes in healthcare industry and making positive impact on people’s lives and our society.

Summary:  Senior Research Associate in Upstream Process Development responsible for executing complex cell culture experiments, maintaining cell lines, optimizing culture conditions, analyzing data, and contributing to development projects with a high level of expertise in aseptic techniques and cell biology. Involved in troubleshooting complex issues, requiring a strong understanding of cell culture principles, proficiency with various cell culture techniques, and experience with data analysis and scientific writing. 

Scope of Responsibilities

·       All aspects of mammalian cell culture including, aseptic technique, media and buffer preparation, culture initiation, propagation.

·       Culturing and purifying different cell types including iPSC and MSC cells.

·       Use of bioreactor systems.

Cell transfection, transduction, and other genetic manipulation techniques. 

Primary human cell isolations, genetic modifications, expansion and cryopreservation

·       Performance of general laboratory tasks, including maintenance of equipment

·       Maintain accurate and reliable records including database management, batch records, lab notebooks, and all other pertinent documentation.

·       Writing and/or contributing to SOPs, batch records, protocols and reports.

·       Comply with all safety and infection control standards.

·       This is a hands-on lab-based position requiring a flexible schedule based on experimental work (some weekend work may be required).

Qualifications

·       Bachelor’s degree in biology, bioengineering, biotechnology, or related discipline with 2 years relevant experience.

·       Strong understanding of tissue culture and aseptic technique.

·       Willingness to work with different viral vector systems (lentiviral and AAV) and biological samples.

·       Strong team worker who is also independently motivated, detail oriented and possesses good problem-solving capabilities.

·       Strong verbal and written skills; able to handle confidential information and material appropriately.

·       Background in bioreactors and/or cell-based methods preferred.

Landmark Bio is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.