Scientist I, Cellular Engineering

At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets.

Position Summary

As Scientist, Cellular Assays you will be responsible for creating and characterizing cellular systems relevant to our protein degradation drug discovery platform and programs, including with neurons, stem cells, and iNeurons. You will develop and optimize high-throughput cellular assays to provide hit-to-lead and mechanism of action studies to early-stage research and discovery programs. By collaborating closely with protein biochemists, biophysicists, and molecular biologists, you will uncover fundamental biology behind targeted regulation of protein homeostasis.

• Design and execute cellular experiments to address scientific questions to progress our programs and contribute to key milestones
• Design, optimize, and run medium to high-throughput cellular screening assays
• Summarize experimental findings and present data clearly and effectively at internal team meetings and external conferences
• Create, maintain, and use a variety of cell lines, including stem cells, neurons, iPSCs, and iNeurons
• Engineer cells using techniques like CRISPR, TALENs, RNAi, transfection, transduction, differentiation, etc.
• Use automation, high-content microscopy, and/or flow cytometry to develop our proprietary platform
• Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals

• Relevant PhD with 0-2 years relevant industry experience; Experience may include postdoc; Experience may be substituted for education.
• Experience with cellular and molecular biology experiments to create and characterize multiple types of cell lines, including human ESCs and/or human iPSCs
• Experience running assays on automated liquid handlers (Bravo, epMotion, Tecan, etc.)
• Experience culturing with sterile technique and maintaining high throughput cell culture assays
• Experience with fluorescence and luminescence detection platforms and high-content microscopy, and/or flow cytometry is a plus
• Experience with challenging cell types, like iNeurons or iPSCs preferred
• Familiarity with CRISPR-based screening or genome editing techniques and prior experience in these areas is preferred
• Ability to keep detailed and organized records of experimental protocols and results
• Ability to manage multiple tasks efficiently, communicate clearly, work within departmental groups, and to build open and collaborative relationships
• Initiative and boldness to dive into a fast-paced new startup

At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success.  We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.