Sr. Associate Scientist, In Vivo Pharmacology

Why join us?

Parabilis Medicines is a highly distinctive young biopharmaceutical company whose intention is to grow over time into the ranks of major therapeutics companies.  Our foundational platform of Helicon™ therapeutics are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

An important distinctive element of Parabilis is our lead program FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor.  This compound is approximately 18 months and ~50 patients into our early development program for patients with advanced solid tumors, most importantly colorectal cancer. There are few products in the ecosystem with the medical and economic potential of FOG-001. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis Medicines is headquartered in Cambridge, Mass.

What’s the opportunity?

The successful candidate will be part of our dedicated, dynamic thinking, and team-driven in vivo pharmacology group that is strongly engaged in the design and execution of pre-clinical activities to evaluate Helicon peptide therapeutics in oncology. It will require key hands-on technical execution and collaboration with external CROs to execute oncology preclinical studies. While acting as an individual contributor, this role has exciting opportunities to grow and develop as a drug hunter, as you will be a key cross-functional team member. As part of this growth, you will learn how to support pre-clinical expansion across oncology indications and communicate preclinical findings to senior leaders across the company. You will work within the existing pharmacology team framework and report directly to the AD of Pharmacology. Success in this role will require an industry understanding of pharmacology with a willingness to understand the scientific background in biology, the ability to manage multiple efforts in parallel, excellent communication skills, and an eagerness to grow as a drug hunter.

Key abilities of this role include

• Execute in vivo studies to support a variety of research efforts, including target validation, therapeutic lead development, and Helicon platform advances
• Support Parabilis in vivo pharmacology studies, both internally and externally
• Participate in biological experiments (-omics, tissue culture, ex vivo) that support our in vivo initiatives
• Perform in vivo PK/PD Efficacy studies to understand Helicon peptide on tumor growth inhibition, MOA, and metabolism
• Act as a dynamic and collaborative in vivo team member who works closely with key stakeholders across our interdisciplinary research group
• Identify and evaluate new in vivo models and technologies to enable novel genetic target validation and screening (transgenic, disease-relevant models, PDX)
• Manage interactions with vendors and CROs
• Prepare clearly articulated experimental reports and data presentations

What you’ll need to be successful:

• BS with 5+ years of experience or MS with 3+ years of experience in the biotech or pharmaceutical industry
• Expertise in human xenograft, PDX, mouse syngeneic, and mouse genetically engineered tumor models
• Experience with multiple modes of drug delivery, including IP, IV, PO, and osmotic pump.
• Experience with in vivo data analysis in support of preclinical and translational studies
• Experience with minor and major surgical techniques, such as animal castration in oncology tumor models
• Experience in drafting and implementing IACUC protocols
• Experience in training and supervision of research associates in the design, execution, and data analysis of in vivo studies
• The candidate must be self-motivated, able to lead and thrive in a team environment, and be comfortable working on and prioritizing multiple projects
• Excellent written and oral communication skills
• Able to work on-site and attend in-person meetings
• Ready to undertake a “moonshot mission,” and work in a fast-paced, highly collaborative, and matrixed environment

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com