Scientist II

• Katalyst Healthcares & Life Sciences is hiring entry level candidates for several positions for contract research in Clinical trials of drugs, biologics and medical devices.
• We have a few immediate job opportunities available in Drug Safety and Pharmacovigilance and Clinical Research field. We work with University hospitals, pharmaceutical companies and recruiting partners.

Job description:
The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team conducts high-throughput screening of physicochemical properties of discovery-stage biologic drug candidates to identify liabilities, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientist to join the client’s Biologics CMC Developability team based in Worcester, MA.

Responsibilities:

• Conduct laboratory-based high-throughput screening and analytical, biophysical, and biochemical characterization of biologic drug candidates.
• Perform experiments to screen physicochemical properties of biologic molecules (antibodies, bispecific antibodies, antibody drug conjugates, and genetic medicine modalities) and identify liabilities that may impact drug development.
• Enable automation and high-throughput screening of discovery candidate molecules.
• Execute experimental protocols, collect results, and perform data analysis independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Requirements:

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3+ (BS) or 1+ years (MS), biopharmaceutical industry experience preferred.
• Hands-on experience in protein biochemical and biophysical characterization. Experience with diverse biologic formats desired.
• Detailed knowledge of protein structure, biophysical characterization, and formulation screening.
• Experience in protein biophysical and biochemical characterization techniques, including chromatography (size-exclusion, ion exchange and hydrophobic interaction chromatography), differential scanning calorimetry & fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged capillary isoelectric focusing, capillary electrophoresis, particle and viscosity measurements. Must be willing and able to learn new technologies as needed.
• Prior experience in high-throughput automation and mass spectrometry would be beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.
• Team player with excellent collaboration and communication skills.

All your information will be kept confidential according to EEO guidelines.